Hevylite可以通過更準確地測量完整的**球蛋白單克隆蛋白來改善對多發(fā)性骨髓瘤患者的監(jiān)測。它是一組獨特的實驗室血清測試，可克服使用電泳方法發(fā)現(xiàn)的一些問題，尤其是在監(jiān)測IgA多發(fā)性骨髓瘤時。
HLC分析提供了檢查漿細胞生物學(xué)和**的新方法。我們能夠發(fā)現(xiàn)以前看不見的異常情況……”
卡茲曼等。白血病2013; 27：1-2
Hevylite是一種簡單的多克隆抗體血清測試，可用于檢測包括多發(fā)性骨髓瘤在內(nèi)的完整**球蛋白單克隆血友病。它可以：
-
當(dāng)SPE和IFE譜帶難以解釋時，準確定量單克隆蛋白
-
準確定量低水平（<10 g / L）的單克隆蛋白
-
確定多發(fā)性骨髓瘤的殘留**
-
比傳統(tǒng)檢測更早發(fā)現(xiàn)多發(fā)性骨髓瘤復(fù)發(fā)
-
與Freelite一起提供*佳監(jiān)控
該測試可提供快速準確的結(jié)果，這些結(jié)果在以下方面起著重要作用：
-
診斷 -為Hevylite提供基線值，可用于監(jiān)視和預(yù)后
-
預(yù)后 -預(yù)測患者預(yù)后
-
監(jiān)測 -評估對**的反應(yīng)
Hevylite是一種快速，簡單且高度靈敏的實驗室血清測試，用于測量完整的**球蛋白單克隆蛋白。它分別識別和測量IgGκ，IgGλ，IgAκ，IgAλ，IgMκ和IgMλ。成對評估這些蛋白質(zhì)，例如IgGκ/IgGλ，以產(chǎn)生比率。
傳統(tǒng)的單克隆血友病血液測試是通過掃描密度測定法進行血清蛋白電泳（SPE或SPEP），CZE（毛細管區(qū)帶電泳）和/或**固定電泳（IFE）以及無血清輕鏈**測定。
Hevylite可以使您的實驗室受益，因為它可以：
-
提供比電泳方法更高的靈敏度
-
克服了電泳觀察到的技術(shù)難題，例如共遷移，非線性和染料飽和
-
通過自動化*大化工作流程并減少“動手”時間
-
提供定量結(jié)果并避免主觀理解凝膠
-
減少獲得結(jié)果所需的不同測試的次數(shù)，尤其是對于IgA單克隆蛋白
Hevylite allows improved monitoring of Multiple Myeloma patients by more accurate measurement of intact immunoglobulin monoclonal proteins. It is a set of unique laboratory serum tests which overcome some of the problems found using electrophoretic methods, especially when monitoring IgA Multiple Myeloma.
“The HLC assays allow new ways to examine plasma cell biology and disease. We are able to identify abnormalities that were previously hidden from our view…”
Katzmann et al. Leukemia 2013;27:1-2
Hevylite is a simple, polyclonal antibody serum test for intact immunoglobulin monoclonal gammopathies including Multiple Myeloma. It can:
-
Accurately quantify monoclonal proteins when SPE and IFE bands are difficult to interpret
-
Accurately quantify monoclonal proteins at low levels (<10 g/L)
-
Identify residual disease in Multiple Myeloma
-
Detect Multiple Myeloma relapse earlier than traditional testing
-
Provide optimal monitoring alongside Freelite
The test provides rapid accurate results that play an important role in:
-
Diagnosis - provides Hevylite a baseline value that is useful in monitoring and prognosis
-
Prognosis - to predict patient outcomes
-
Monitoring - to measure response to treatment
Hevylite is a quick, simple and highly sensitive laboratory serum test for measuring intact immunoglobulin monoclonal proteins. It identifies and measures IgGκ, IgGλ, IgAκ, IgAλ, IgMκ and IgMλ individually. These proteins are assessed in pairs, e.g. IgGκ/IgGλ, to produce ratios.
Traditional blood tests for monoclonal gammopathies are serum protein electrophoresis (SPE or SPEP) with scanning densitometry, CZE (capillary zone electrophoresis) and/or immunofixation electrophoresis (IFE) together with serum free light chain immunoassays.
Hevylite can benefit your lab because it:
-
provides greater sensitivity than electrophoretic methods
-
overcomes technical challenges observed with electrophoresis such as co-migration, non-linearity and dye saturation
-
maximizes workflow through automation and reduces “hands-on” time
-
provides quantitative results and avoids subjective interpretation of gels
-
reduces the number of different tests needed to get a result, especially for IgA monoclonal proteins
-
